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Fak structure from single particle analysis of 2D crystals

Analyse Fak structure from single particle analysis of 2D crystals in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TY3
Type: protein
Length: 1,200 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Focal adhesion kinase 1
EC: 2.7.10.2
UniProt: Q00944
Pockets: 18 · best druggability 0.86

Structure

electron microscopy · 1 distinct chain · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Focal adhesion kinase 1 (EC 2.7.10.2)	protein	600	38% helix, 16% strand	Q00944

Pockets

18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1151	0.86	0.86	125	empty
2	1043	0.83	0.84	129	empty
3	943	0.82	0.84	82	empty
4	56	0.67	0.95	19	empty
5	148	0.66	0.87	31	empty

Interfaces

1 interface between chains.

A–B · 1724 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6TY3 · FAK structure from single particle analysis of 2D crystals · the same entry in another collection · chain A against A, TM-score 1.00
Q00944 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q00944) · a predicted model of the same protein · chain A against A, TM-score 0.55

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00944
Elsewhere: RCSB PDB 6TY3 · PDBe 6TY3 · UniProt Q00944

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