Research workbench
Unliganded human CD73 (5'-nucleotidase) in the open state
Analyse Unliganded human CD73 (5'-nucleotidase) in the open state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TVE
- Type
- protein
- Length
- 524 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-nucleotidase
- EC
- 3.1.3.5
- UniProt
- P21589
- Ligands
- ZN, CA
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| P | 5'-nucleotidase (EC 3.1.3.5) | protein | 524 | 31% helix, 26% strand | P21589 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains P
- CA · Calcium ion · metal · chains P
- DMS · Dimethyl sulfoxide · additive · 8 copies · chains P
- GOL · Glycerol · additive · 3 copies · chains P
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.64 | 0.77 | 61 | DMS |
| 2 | 283 | 0.63 | 0.81 | 35 | empty |
| 3 | 127 | 0.44 | 0.77 | 23 | GOL |
| 4 | 72 | 0.32 | 0.74 | 20 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21589
- Elsewhere: RCSB PDB 6TVE · PDBe 6TVE · UniProt P21589
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.