Research workbench
Ef-hands 3 and 4 of alpha-actinin in complex with camkii regulatory segment
Analyse Ef-hands 3 and 4 of alpha-actinin in complex with camkii regulatory segment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TS3
- Type
- protein
- Length
- 180 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-actinin-2; ACE-asn-ala-arg-arg-lys-leu-lys-gly-ala-ile-leu-thr-thr…
- UniProt
- P35609
- Ligands
- ACE
Structure
x-ray diffraction · 4 distinct chains · 62% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-actinin-2 | protein | 73 | 58% helix, 4% strand | P35609 |
| B | Alpha-actinin-2 | protein | 70 | 60% helix, 4% strand | P35609 |
| C | ACE-asn-ala-arg-arg-lys-leu-lys-gly-ala-ile-leu-thr-thr- met-leu-ala-thr-arg-asn-phe | protein | 20 | 75% helix, 0% strand | — |
| D | ACE-asn-ala-arg-arg-lys-leu-lys-gly-ala-ile-leu-thr-thr- met-leu-ala-thr-arg-asn-phe | protein | 17 | 76% helix, 0% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · 2 copies · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
6 interfaces between chains.
- A–C · 710 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 577 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 257 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 235 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 197 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 6TS3 · EF-hands 3 and 4 of alpha-actinin in complex with CaMKII regulatory segment · the same entry in another collection · chain A against A, TM-score 1.00
- P35609 · AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35609
- Elsewhere: RCSB PDB 6TS3 · PDBe 6TS3 · UniProt P35609
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.