Research workbench
Structural insight into tanapoxvirus mediated inhibition of apoptosis
Analyse Structural insight into tanapoxvirus mediated inhibition of apoptosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TQQ
- Type
- protein
- Length
- 159 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 16L protein; BCL-2-like protein 11
- UniProt
- Q9DHU6, O43521
- Ligands
- NA
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 16L protein | protein | 137 | 81% helix, 0% strand | Q9DHU6 |
| B | BCL-2-like protein 11 | protein | 22 | 91% helix, 0% strand | O43521 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.52 | 0.73 | 24 | empty |
| 2 | 60 | 0.36 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 944 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6TQQ · Structural insight into tanapoxvirus mediated inhibition of apoptosis · the same entry in another collection · chain A against A, TM-score 1.00
- O43521 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 11 (O43521) · a predicted model of the same protein · chain B against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9DHU6
- Every structure of UniProt O43521
- Elsewhere: RCSB PDB 6TQQ · PDBe 6TQQ · UniProt Q9DHU6 · UniProt O43521
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