Research workbench
Rabies virus glycoprotein pH domain in complex with the scfv fragment of broadly neutralizing human antibody RVC20
Analyse Rabies virus glycoprotein pH domain in complex with the scfv fragment of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TOU
- Type
- protein
- Length
- 303 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GLYCOPROTEIN,GLYCOPROTEIN; Single-chain fv
- UniProt
- Q8JUA9
- Ligands
- CA, CL
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | GLYCOPROTEIN,GLYCOPROTEIN | protein | 71 | 0% helix, 42% strand | Q8JUA9 |
| A | Single-chain fv | protein | 232 | 3% helix, 49% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 203 | 0.50 | 0.76 | 27 | empty |
| 2 | 80 | 0.32 | 0.74 | 19 | empty |
| 3 | 53 | 0.28 | 0.75 | 20 | empty |
| 4 | 57 | 0.27 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- G–A · 766 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6TOU · Rabies virus glycoprotein PH domain in complex with the scFv fragment of broadly… · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8JUA9
- Elsewhere: RCSB PDB 6TOU · PDBe 6TOU · UniProt Q8JUA9
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