Research workbench
Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
Analyse Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TM1
- Type
- protein
- Length
- 977 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dedicator of cytokinesis protein 10; RAS-related C3 botulinum toxin substrate 3
- UniProt
- Q96BY6, P60763
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Dedicator of cytokinesis protein 10 | protein | 412 | 46% helix, 10% strand | Q96BY6 |
| A | RAS-related C3 botulinum toxin substrate 3 | protein | 177 | 34% helix, 18% strand | P60763 |
| C | Dedicator of cytokinesis protein 10 | protein | 388 | 46% helix, 12% strand | Q96BY6 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.76 | 0.90 | 41 | empty |
| 2 | 218 | 0.75 | 0.89 | 47 | empty |
| 3 | 714 | 0.74 | 0.79 | 65 | empty |
| 4 | 1139 | 0.73 | 0.76 | 99 | empty |
| 5 | 57 | 0.73 | 0.98 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–A · 1892 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 173 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 130 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6TM1 · Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3 · the same entry in another collection · chain B against B, TM-score 1.00
- Q96BY6 · AlphaFold monomer V2.0 prediction for dedicator of cytokinesis protein 10 (Q96BY6) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P60763 · AlphaFold monomer V2.0 prediction for RAS-related C3 botulinum toxin substrate 3 (P60763) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96BY6
- Every structure of UniProt P60763
- Elsewhere: RCSB PDB 6TM1 · PDBe 6TM1 · UniProt Q96BY6 · UniProt P60763
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