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Femtosecond to millisecond structural changes in a light-driven sodium pump: 1MS structure of KR2 with extrapolated, light and dark datasets

Analyse Femtosecond to millisecond structural changes in a light-driven sodium pump… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TK2
Type: protein
Length: 265 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sodium pumping rhodopsin
UniProt: N0DKS8
Ligands: LFA, RET, NA
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sodium pumping rhodopsin	protein	265	77% helix, 3% strand	N0DKS8

Ligands and binding sites

LFA · Eicosane · ligand · 26 copies · chains A
RET · Retinal · ligand · chains A
NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.76	0.93	25	RET, LFA

Modifications

Observed in the structure: 1 cofactor (retinal Schiff base).

Compared structures

6TK2 · Femtosecond to millisecond structural changes in a light-driven sodium pump: 1ms… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt N0DKS8
Elsewhere: RCSB PDB 6TK2 · PDBe 6TK2 · UniProt N0DKS8

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