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Cryo-EM structure of P62-PB1 filament (S-type)

Analyse Cryo-EM structure of P62-PB1 filament (S-type) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TH3
Type: protein
Length: 312 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sequestosome-1
UniProt: Q13501
Pockets: 1 · best druggability 0.34

Structure

electron microscopy · 1 distinct chain · 18% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Sequestosome-1	protein	104	18% helix, 31% strand	Q13501

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.34	0.78	11	empty

Interfaces

2 interfaces between chains.

A–C · 129 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 68 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6TH3 · Cryo-EM structure of p62-PB1 filament (S-type) · the same entry in another collection · chain A against A, TM-score 1.00
Q13501 · AlphaFold monomer V2.0 prediction for sequestosome-1 (Q13501) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13501
Elsewhere: RCSB PDB 6TH3 · PDBe 6TH3 · UniProt Q13501

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