Research workbench

Urocanate reductase in complex with urocanate

Analyse Urocanate reductase in complex with urocanate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6T87
Type: protein
Length: 454 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urocanate reductase
EC: 1.3.99.33
UniProt: Q8CVD0
Ligands: FAD, URO, NA, SO4, CL
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Urocanate reductase (EC 1.3.99.33)	protein	454	37% helix, 24% strand	Q8CVD0

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A
URO · (2E)-3-(1H-imidazol-4-yl)acrylic acid · ligand · chains A
NA · Sodium ion · metal · chains A
SO4 · Sulfate ion · ion · 4 copies · chains A
CL · Chloride ion · ion · 2 copies · chains A
GOL · Glycerol · additive · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	528	0.82	0.88	84	FAD, URO, GOL, SO4
2	95	0.39	0.77	17	empty
3	64	0.27	0.73	18	empty

Compared structures

6T87 · Urocanate reductase in complex with urocanate · the same entry in another collection · chain A against A, TM-score 1.00
Q8CVD0 · AlphaFold monomer V2.0 prediction for urocanate reductase (Q8CVD0) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CVD0
Elsewhere: RCSB PDB 6T87 · PDBe 6T87 · UniProt Q8CVD0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.