Research workbench
Crystal structure of drosophila melanogaster glutathione S-transferase epsilon 14 in complex with glutathione and 2-methyl-2,4-pentanediol
Analyse Crystal structure of drosophila melanogaster glutathione S-transferase epsilon… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6T2T
- Type
- protein
- Length
- 229 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase E14
- EC
- 2.5.1.18
- UniProt
- Q7JYX0
- Ligands
- GSH
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 59% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione S-transferase E14 (EC 2.5.1.18) | protein | 229 | 59% helix, 7% strand | Q7JYX0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.61 | 0.79 | 29 | GSH, MPD |
| 2 | 63 | 0.42 | 0.81 | 15 | empty |
Compared structures
- 6T2T · Crystal structure of Drosophila melanogaster glutathione S-transferase epsilon 14 in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q7JYX0 · AlphaFold monomer V2.0 prediction for glutathione S-transferase E14 (Q7JYX0) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7JYX0
- Elsewhere: RCSB PDB 6T2T · PDBe 6T2T · UniProt Q7JYX0
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