UniProt Q7JYX0
Glutathione S-transferase E14 (Q7JYX0)
Glutathione S-transferase E14 (UniProt Q7JYX0), EC 2.5.1.18: 25 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q7JYX0
- Protein
- Glutathione S-transferase E14
- EC
- 2.5.1.18
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 54 · 14 records with a druggable one
Structures
26 records of Q7JYX0 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6KEL | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | AA, BA | — | 4 (best 0.84) |
| 6KEM | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | AA, BA | — | 4 (best 0.84) |
| 6KEN | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | AA, BA | GSH | 4 (best 0.82) |
| 6KEO | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | AA, BA | EST | — |
| 6KEP | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | AA, BA | GSH, EST | 4 (best 0.84) |
| 6KEQ | Crystal structure of D113A mutant of Drosophila melanogaster Noppera-bo, glutathione S-transferase… | x-ray diffraction | AA, BA | — | 4 (best 0.81) |
| 6KER | Crystal structure of D113A mutant of Drosophila melanogaster Noppera-bo, glutathione S-transferase… | x-ray diffraction | AA, BA | GSH | 4 (best 0.81) |
| 6T2T | Crystal structure of Drosophila melanogaster glutathione S-transferase epsilon 14 in complex with… | x-ray diffraction | A | GSH | 2 (best 0.61) |
| 6T2T | Crystal structure of drosophila melanogaster glutathione S-transferase epsilon 14 in complex with… | x-ray diffraction | A | GSH | — |
| 7DAX | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H1X, CL | 4 (best 0.82) |
| 7DAX | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H1X, CL | — |
| 7DAY | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H1X, GSH | — |
| 7DAY | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H1X, GSH | — |
| 7DAZ | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | GSH, H29 | 5 (best 0.76) |
| 7DAZ | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | GSH, H29 | — |
| 7DB0 | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | DC1 | 5 (best 0.80) |
| 7DB0 | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | DC1 | — |
| 7DB1 | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | DC1, GSH | 3 (best 0.79) |
| 7DB1 | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | DC1, GSH | — |
| 7DB2 | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | DC1, GSH | 4 (best 0.82) |
| 7DB2 | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | DC1, GSH | — |
| 7DB3 | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H2X, GSH | 3 (best 0.80) |
| 7DB3 | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H2X, GSH | — |
| 7DB4 | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H2C, GSH | 4 (best 0.80) |
| 7DB4 | Crystal structure of drosophila melanogaster noppera-bo, glutathione S-transferase epsilon 14… | x-ray diffraction | A, B | H2C, GSH | — |
| Q7JYX0 | AlphaFold monomer V2.0 prediction for glutathione S-transferase E14 (Q7JYX0) | predicted | A | — | — |
Ligands
- GSH · Glutathione · in 17 records
- DC1 · 5,5-dimethylcyclohexane-1,3-dione · in 6 records
- H1X · 2-[(5-tert-butyl-2-methyl-phenyl)sulfonylamino]benzoic acid · in 4 records
- CL · Chloride ion · in 2 records
- EST · Estradiol · in 2 records
- H29 · 6-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)pyridin-3-amine · in 2 records
- H2C · 1-[(4-fluorophenyl)methyl]-2,2-bis(oxidanylidene) thieno[3,2-c][1,2]thiazin-4-one · in 2 records
- H2X · 4-bromanyl-2-[[2-[(E)-1-(3-methoxyphenyl) ethylideneamino]propan-2-ylamino]methyl]phenol · in 2 records
Experiment against prediction
- 6KER chain BA against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.62 Å
- 7DB1 chain B against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.62 Å
- 7DB1 chain B against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.62 Å
- 7DB3 chain B against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.62 Å
- 7DB3 chain B against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.62 Å
- 6KEQ chain BA against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.64 Å
- 7DAX chain B against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.65 Å
- 7DAX chain B against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.65 Å
- 6KEP chain BA against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.67 Å
- 6KEO chain BA against the predicted model Q7JYX0: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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