Research workbench
Wolinella succinogenes L-asparaginase mutant V23Q,K24T in P 22121
Analyse Wolinella succinogenes L-asparaginase mutant V23Q,K24T in P 22121 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SYH
- Type
- protein
- Length
- 631 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-asparaginase
- EC
- 3.5.1.1
- UniProt
- P50286
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-asparaginase (EC 3.5.1.1) | protein | 318 | 34% helix, 20% strand | P50286 |
| B | L-asparaginase (EC 3.5.1.1) | protein | 313 | 32% helix, 21% strand | P50286 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.67 | 0.95 | 28 | empty |
| 2 | 181 | 0.48 | 0.77 | 27 | empty |
| 3 | 178 | 0.44 | 0.74 | 26 | empty |
| 4 | 65 | 0.36 | 0.78 | 17 | empty |
| 5 | 60 | 0.32 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2018 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50286
- Elsewhere: RCSB PDB 6SYH · PDBe 6SYH · UniProt P50286
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