UniProt P50286
L-asparaginase (P50286)
L-asparaginase (UniProt P50286), EC 3.5.1.1: 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P50286
- Protein
- L-asparaginase
- EC
- 3.5.1.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 32 · 3 records with a druggable one
Structures
15 records of P50286 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WSA | Structure of L-asparaginase II precursor | x-ray diffraction | A, B | — | — |
| 1WSA | Structure of L-asparaginase II precursor | x-ray diffraction | A, B | — | — |
| 5K3O | Wolinella succinogenes L-asparaginase P121 and L-Aspartic acid | x-ray diffraction | A, B, C, D | — | — |
| 5K3O | Wolinella succinogenes L-asparaginase P121 and L-aspartic acid | x-ray diffraction | A, B, C, D | — | — |
| 5K45 | Wolinella succinogenes L-asparaginase P121 + L-Glutamic acid | x-ray diffraction | A, B, C, D | GLU | 11 (best 0.73) |
| 5K45 | Wolinella succinogenes L-asparaginase P121 + L-glutamic acid | x-ray diffraction | A, B, C, D | — | — |
| 5K4G | Wolinella succinogenes L-asparaginase S121 + L-aspartic acid, open conformation | x-ray diffraction | A, B, C, D | — | — |
| 5K4H | Wolinella succinogenes L-asparaginase S121 + L-glutamic acid | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6RUD | Wolinella succinogenes L-asparaginase P1 | x-ray diffraction | A, B, C, D | — | — |
| 6RUE | Wolinella succinogenes L-asparaginase mutant V23Q,K24T with L-Asp | x-ray diffraction | A, B, C, D | ASP | 10 (best 0.84) |
| 6RUE | Wolinella succinogenes L-asparaginase mutant V23Q,K24T with L-asp | x-ray diffraction | A, B, C, D | — | — |
| 6RUF | Wolinella succinogenes L-asparaginase mutant V23Q,K24T with L-Glu | x-ray diffraction | A, B, C, D | GLU | 11 (best 0.82) |
| 6RUF | Wolinella succinogenes L-asparaginase mutant V23Q,K24T with L-glu | x-ray diffraction | A, B, C, D | — | — |
| 6SYH | Wolinella succinogenes L-asparaginase mutant V23Q,K24T in P 22121 | x-ray diffraction | A, B | — | — |
| P50286 | AlphaFold monomer V2.0 prediction for L-asparaginase (P50286) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6RUE chain C against the predicted model P50286: TM-score 1.00, RMSD 0.38 Å
- 6RUE chain B against the predicted model P50286: TM-score 1.00, RMSD 0.38 Å
- 6RUE chain D against the predicted model P50286: TM-score 1.00, RMSD 0.43 Å
- 5K3O chain C against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
- 5K3O chain C against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
- 5K3O chain A against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
- 5K3O chain A against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
- 5K3O chain B against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
- 5K3O chain B against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
- 5K3O chain D against the predicted model P50286: TM-score 0.99, RMSD 0.38 Å
Elsewhere
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