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AFFIMER9 co-crystalised with the ch domains of alpha actinin 2.

Analyse AFFIMER9 co-crystalised with the ch domains of alpha actinin 2. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SWT
Type: protein
Length: 316 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-actinin-2; Affimer 9
UniProt: P35609
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-actinin-2	protein	228	61% helix, 2% strand	P35609
B	Affimer 9	protein	88	20% helix, 57% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.40	0.76	19	empty
2	64	0.35	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 629 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6SWT · Affimer9 co-crystalised with the CH domains of alpha actinin 2. · the same entry in another collection · chain A against A, TM-score 1.00
P35609 · AlphaFold monomer V2.0 prediction for alpha-actinin-2 (P35609) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35609
Elsewhere: RCSB PDB 6SWT · PDBe 6SWT · UniProt P35609

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