Research workbench
Crystal structure of glutathione transferase omega 2C from trametes versicolor in complex with naringenin
Analyse Crystal structure of glutathione transferase omega 2C from trametes versicolor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SRA
- Type
- protein
- Length
- 469 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione transferase
- UniProt
- R7S7J5
- Ligands
- GSH, CWE
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione transferase | protein | 235 | 56% helix, 8% strand | R7S7J5 |
| B | Glutathione transferase | protein | 234 | 56% helix, 9% strand | R7S7J5 |
Ligands and binding sites
- GSH · Glutathione · ligand · 2 copies · chains A, B
- CWE · R-naringenin · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 572 | 0.66 | 0.76 | 49 | GSH |
| 2 | 243 | 0.54 | 0.76 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 280 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 6SRA · Crystal structure of glutathione transferase Omega 2C from Trametes versicolor in complex… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R7S7J5
- Elsewhere: RCSB PDB 6SRA · PDBe 6SRA · UniProt R7S7J5
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