Research workbench
Crystal structure of mouse PRMT6 with partial C-terminal tev cleavage site
Analyse Crystal structure of mouse PRMT6 with partial C-terminal tev cleavage site in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SQH
- Type
- protein
- Length
- 645 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 6
- EC
- 2.1.1.319
- UniProt
- Q6NZB1
- Pockets
- 6 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 6 (EC 2.1.1.319) | protein | 321 | 30% helix, 36% strand | Q6NZB1 |
| B | Protein arginine N-methyltransferase 6 (EC 2.1.1.319) | protein | 324 | 30% helix, 37% strand | Q6NZB1 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 310 | 0.64 | 0.80 | 37 | empty |
| 2 | 266 | 0.62 | 0.80 | 38 | empty |
| 3 | 123 | 0.56 | 0.83 | 19 | empty |
| 4 | 111 | 0.53 | 0.82 | 16 | empty |
| 5 | 96 | 0.40 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2044 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6SQH · Crystal structure of mouse PRMT6 with partial C-terminal TEV cleavage site · the same entry in another collection · chain A against A, TM-score 1.00
- Q6NZB1 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 6 (Q6NZB1) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6NZB1
- Elsewhere: RCSB PDB 6SQH · PDBe 6SQH · UniProt Q6NZB1
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