Research workbench
Crystal structure of the human INTS13-INTS14 complex
Analyse Crystal structure of the human INTS13-INTS14 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SN1
- Type
- protein
- Length
- 1,020 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrator complex subunit 13; Integrator complex subunit 14
- UniProt
- Q9NVM9, Q96SY0
- Ligands
- SO4
- Pockets
- 11 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrator complex subunit 13 | protein | 517 | 40% helix, 22% strand | Q9NVM9 |
| B | Integrator complex subunit 14 | protein | 503 | 37% helix, 19% strand | Q96SY0 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 846 | 0.74 | 0.78 | 85 | empty |
| 2 | 406 | 0.69 | 0.81 | 53 | SO4 |
| 3 | 342 | 0.66 | 0.80 | 36 | SO4 |
| 4 | 305 | 0.65 | 0.81 | 37 | empty |
| 5 | 307 | 0.64 | 0.80 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 5299 Ų buried · 54 hydrogen bonds · protein-protein
Compared structures
- 6SN1 · Crystal structure of the human INTS13-INTS14 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96SY0 · AlphaFold monomer V2.0 prediction for integrator complex subunit 14 (Q96SY0) · a predicted model of the same protein · chain B against A, TM-score 0.73
- Q9NVM9 · AlphaFold monomer V2.0 prediction for integrator complex subunit 13 (Q9NVM9) · a predicted model of the same protein · chain A against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NVM9
- Every structure of UniProt Q96SY0
- Elsewhere: RCSB PDB 6SN1 · PDBe 6SN1 · UniProt Q9NVM9 · UniProt Q96SY0
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