UniProt Q96SY0
Integrator complex subunit 14 (Q96SY0)
Integrator complex subunit 14 (UniProt Q96SY0): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96SY0
- Protein
- Integrator complex subunit 14
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 70 · 10 records with a druggable one
Structures
11 records of Q96SY0 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6SN1 | Crystal structure of the human INTS13-INTS14 complex | x-ray diffraction | B | SO4 | 11 (best 0.74) |
| 6SN1 | Crystal structure of the human INTS13-INTS14 complex | x-ray diffraction | B | SO4 | — |
| 8PK5 | INTS13-INTS14 complex with ZNF609 | x-ray diffraction | B | MG | 10 (best 0.75) |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | n | — | 3 (best 0.85) |
| 8RBZ | Structure of Integrator-PP2A-SOSS-CTD post-termination complex | electron microscopy | n | — | 1 (best 0.75) |
| 8RC4 | Structure of Integrator-PP2A complex | electron microscopy | n | — | 4 (best 0.81) |
| 9EOC | Structure of the Integrator arm module containing INTS10/13/14 subunits | electron microscopy | B | MG | 10 (best 0.73) |
| 9EP1 | Structure of the Integrator arm module containing INTS10/13/14/15 subunits (state 2) | electron microscopy | B | — | 8 (best 0.71) |
| 9FA4 | Structure of the Integrator arm module containing subunits INTS10/13/14/15 (state 1) | electron microscopy | B | — | 10 (best 0.80) |
| 9FA7 | Structure of the Integrator arm module containing subunits INTS10/13/14/15 (state 3) | electron microscopy | B | — | 10 (best 0.72) |
| Q96SY0 | AlphaFold monomer V2.0 prediction for integrator complex subunit 14 (Q96SY0) | predicted | A | — | 3 (best 0.57) |
Ligands
Experiment against prediction
- 9EP1 chain B against the predicted model Q96SY0: TM-score 0.76, RMSD 3.15 Å
- 9FA7 chain B against the predicted model Q96SY0: TM-score 0.76, RMSD 3.03 Å
- 9EOC chain B against the predicted model Q96SY0: TM-score 0.76, RMSD 3.02 Å
- 9FA4 chain B against the predicted model Q96SY0: TM-score 0.76, RMSD 2.99 Å
- 6SN1 chain B against the predicted model Q96SY0: TM-score 0.73, RMSD 3.24 Å
- 6SN1 chain B against the predicted model Q96SY0: TM-score 0.73, RMSD 3.24 Å
- 8PK5 chain B against the predicted model Q96SY0: TM-score 0.70, RMSD 3.46 Å
- 8RBZ chain n against the predicted model Q96SY0: TM-score 0.61, RMSD 4.57 Å
- 8RBX chain n against the predicted model Q96SY0: TM-score 0.51, RMSD 6.37 Å
- 8RC4 chain n against the predicted model Q96SY0: TM-score 0.51, RMSD 6.26 Å
Elsewhere
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