Research workbench

MBC/SHP1-C-SH2 complex

Analyse MBC/SHP1-C-SH2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SM5
Type: protein
Length: 197 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 6; Mbc (monobody targeting SHP1-C-SH2)
EC: 3.1.3.48
UniProt: P29350
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)	protein	106	20% helix, 42% strand	P29350
B	Mbc (monobody targeting SHP1-C-SH2)	protein	91	0% helix, 57% strand	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	135	0.53	0.81	22	empty
2	119	0.52	0.81	30	empty

Interfaces

1 interface between chains.

A–B · 900 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6SM5 · MbC/SHP1-C-SH2 complex · the same entry in another collection · chain A against A, TM-score 1.00
P29350 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 6… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29350
Elsewhere: RCSB PDB 6SM5 · PDBe 6SM5 · UniProt P29350

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