Research workbench
Flavin-dependent tryptophan 6-halogenase thal in complex with tryptophan and FAD
Analyse Flavin-dependent tryptophan 6-halogenase thal in complex with tryptophan and FAD in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SLT
- Type
- protein
- Length
- 1,053 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan 6-halogenase
- UniProt
- A1E280
- Ligands
- TRP, AMP, FAD, PO4
- Pockets
- 16 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan 6-halogenase | protein | 528 | 41% helix, 20% strand | A1E280 |
| B | Tryptophan 6-halogenase | protein | 525 | 39% helix, 20% strand | A1E280 |
Ligands and binding sites
- TRP · Tryptophan · ligand · chains A
- AMP · Adenosine monophosphate · ligand · chains A
- FAD · Flavin-adenine dinucleotide · ligand · chains B
- PO4 · Phosphate ion · ion · 3 copies · chains A, B
- GOL · Glycerol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.81 | 0.90 | 53 | FAD |
| 2 | 829 | 0.76 | 0.80 | 69 | GOL, AMP |
| 3 | 876 | 0.75 | 0.79 | 62 | GOL |
| 4 | 74 | 0.75 | 0.98 | 23 | TRP |
| 5 | 55 | 0.67 | 0.96 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2125 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- 6SLT · Flavin-dependent tryptophan 6-halogenase Thal in complex with tryptophan and FAD · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A1E280
- Elsewhere: RCSB PDB 6SLT · PDBe 6SLT · UniProt A1E280
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.