Research workbench
Crystal structure of the human deah-helicase DHX15 in complex with the nkrf G-patch
Analyse Crystal structure of the human deah-helicase DHX15 in complex with the nkrf… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SH7
- Type
- protein
- Length
- 711 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Nf-kappa-B-repressing factor
- EC
- 3.6.4.13
- UniProt
- O43143, O15226
- Pockets
- 9 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) | protein | 665 | 43% helix, 18% strand | O43143 |
| B | Nf-kappa-B-repressing factor | protein | 46 | 15% helix, 0% strand | O15226 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1107 | 0.84 | 0.85 | 130 | empty |
| 2 | 326 | 0.66 | 0.81 | 33 | empty |
| 3 | 206 | 0.60 | 0.81 | 30 | empty |
| 4 | 89 | 0.54 | 0.85 | 18 | empty |
| 5 | 256 | 0.54 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 2067 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6SH7 · Crystal structure of the human DEAH-helicase DHX15 in complex with the NKRF G-patch · the same entry in another collection · chain A against A, TM-score 1.00
- O43143 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent RNA… · a predicted model of the same protein · chain A against A, TM-score 0.98
- O15226 · AlphaFold monomer V2.0 prediction for nf-kappa-B-repressing factor (O15226) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43143
- Every structure of UniProt O15226
- Elsewhere: RCSB PDB 6SH7 · PDBe 6SH7 · UniProt O43143 · UniProt O15226
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