UniProt O43143
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (O43143)
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (UniProt O43143), EC 3.6.4.13: 10 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 36 pockets. Binding sites, druggability and experiment…
- UniProt
- O43143
- Protein
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
- EC
- 3.6.4.13
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 36 · 6 records with a druggable one
Structures
11 records of O43143 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5XDR | Crystal structure of human DEAH-box RNA helicase DHX15 in complex with ADP | x-ray diffraction | A | ADP, SO4, MG | 10 (best 0.84) |
| 5XDR | Crystal structure of human deah-box RNA helicase DHX15 in complex with ADP | x-ray diffraction | A | ADP, SO4, MG | — |
| 6ID1 | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9… | electron microscopy | V | — | 1 (best 0.81) |
| 6ID1 | Cryo-EM structure of a human intron lariat spliceosome after PRP43 loaded (ILS2 complex) at 2.9… | electron microscopy | V | — | — |
| 6SH6 | Crystal structure of the human DEAH-helicase DHX15 in complex with the NKRF G-patch bound to ADP | x-ray diffraction | A | ADP, MG | 7 (best 0.84) |
| 6SH6 | Crystal structure of the human deah-helicase DHX15 in complex with the nkrf G-patch bound to ADP | x-ray diffraction | A | ADP, MG | — |
| 6SH7 | Crystal structure of the human DEAH-helicase DHX15 in complex with the NKRF G-patch | x-ray diffraction | A | — | 9 (best 0.84) |
| 6SH7 | Crystal structure of the human deah-helicase DHX15 in complex with the nkrf G-patch | x-ray diffraction | A | — | — |
| 8EJM | Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch | x-ray diffraction | A | ADP, MG, SO4, CL | 7 (best 0.84) |
| 8RO2 | Integrative Structure of the human intron lariat Spliceosome (ILS'') | electron microscopy | DX | — | 2 (best 0.84) |
| O43143 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent RNA helicase DHX15… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8RO2 chain DX against the predicted model O43143: TM-score 0.99, RMSD 0.85 Å
- 8EJM chain A against the predicted model O43143: TM-score 0.99, RMSD 1.03 Å
- 6ID1 chain V against the predicted model O43143: TM-score 0.99, RMSD 1.10 Å
- 6ID1 chain V against the predicted model O43143: TM-score 0.99, RMSD 1.10 Å
- 5XDR chain A against the predicted model O43143: TM-score 0.98, RMSD 1.31 Å
- 5XDR chain A against the predicted model O43143: TM-score 0.98, RMSD 1.31 Å
- 6SH7 chain A against the predicted model O43143: TM-score 0.98, RMSD 1.11 Å
- 6SH7 chain A against the predicted model O43143: TM-score 0.98, RMSD 1.11 Å
- 6SH6 chain A against the predicted model O43143: TM-score 0.98, RMSD 1.12 Å
- 6SH6 chain A against the predicted model O43143: TM-score 0.98, RMSD 1.12 Å
Elsewhere
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