MolNFT v1 · #163901 · protein

Crystal structure of the human deah-helicase DHX15 in complex with the nkrf G-patch bound to ADP

6SH6 · Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15: “Crystal structure of the human deah-helicase DHX15 in complex with the nkrf G-patch bound to ADP”. X-ray diffraction, 2 ligands (ADP, MG), 7 pockets (best druggability…

PDB: 6SH6
Type: protein
Length: 722 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Nf-kappa-B-repressing factor
EC: 3.6.4.13
UniProt: O43143, O15226
Ligands: ADP, MG
Pockets: 7 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13)	protein	681	42% helix, 18% strand	O43143
B	Nf-kappa-B-repressing factor	protein	41	20% helix, 0% strand	O15226

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1194	0.84	0.85	129	empty
2	347	0.71	0.83	33	ADP, EDO, MG
3	341	0.67	0.81	34	empty
4	250	0.53	0.76	22	empty
5	84	0.50	0.83	16	empty

Interfaces

1 interface between chains.

A–B · 1928 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6SH6 · Crystal structure of the human DEAH-helicase DHX15 in complex with the NKRF G-patch bound… · the same entry in another collection · chain A against A, TM-score 1.00
O43143 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent RNA… · a predicted model of the same protein · chain A against A, TM-score 0.98
O15226 · AlphaFold monomer V2.0 prediction for nf-kappa-B-repressing factor (O15226) · a predicted model of the same protein · chain B against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43143
Every structure of UniProt O15226
Elsewhere: RCSB PDB 6SH6 · PDBe 6SH6 · UniProt O43143 · UniProt O15226

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.