Atomic resolution structure of human carbonic anhydrase II in complex with (R)-5-phenyloxazolidine-2,4-dione

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 30% strand (DSSP).

Ligands and binding sites

• 7Q1 · (5R)-5-phenyl-1,3-oxazolidine-2,4-dione · ligand · chains A
• BE7 · (4-carboxyphenyl)(chloro)mercury · ligand · chains A
• HG · Mercury (II) ion · metal · 2 copies · chains A
• ZN · Zinc ion · metal · chains A
• NA · Sodium ion · metal · chains A
• DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6SFQ · Atomic resolution structure of human Carbonic Anhydrase II in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00918
• Elsewhere: RCSB PDB 6SFQ · PDBe 6SFQ · UniProt P00918