Research workbench

MAPK14 with bound inhibitor sr-318

Analyse MAPK14 with bound inhibitor sr-318 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SFO
Type: protein
Length: 334 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase 14
EC: 2.7.11.24
UniProt: Q16539
Ligands: LBE, NA
Pockets: 5 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitogen-activated protein kinase 14 (EC 2.7.11.24)	protein	334	37% helix, 14% strand	Q16539

Ligands and binding sites

LBE · 5-azanyl-~{N}-[[4-(3-cyclohexylpropylcarbamoyl) phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · ligand · chains A
NA · Sodium ion · metal · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	451	0.73	0.82	50	LBE
2	260	0.71	0.86	23	empty
3	97	0.37	0.75	17	empty
4	69	0.32	0.75	18	empty
5	57	0.31	0.75	15	empty

Compared structures

6SFO · MAPK14 with bound inhibitor SR-318 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16539
Elsewhere: RCSB PDB 6SFO · PDBe 6SFO · UniProt Q16539

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.