Research workbench
Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on SER139 and SER164
Analyse Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SAD
- Type
- protein
- Length
- 485 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein gamma; Caspase-2
- EC
- 3.4.22.55
- UniProt
- P61981, P42575
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 14-3-3 protein gamma | protein | 233 | 80% helix, 0% strand | P61981 |
| C | Caspase-2 (EC 3.4.22.55) | protein | 19 | 0% helix, 0% strand | P42575 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 241 | 0.61 | 0.81 | 31 | empty |
| 2 | 144 | 0.54 | 0.81 | 20 | empty |
| 3 | 276 | 0.50 | 0.74 | 26 | empty |
| 4 | 69 | 0.28 | 0.73 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1019 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 789 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 400 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6SAD · Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on… · the same entry in another collection · chain A against A, TM-score 1.00
- P61981 · AlphaFold monomer V2.0 prediction for 14-3-3 protein gamma (P61981) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P42575 · AlphaFold monomer V2.0 prediction for caspase-2 (P42575) · a predicted model of the same protein · chain C against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61981
- Every structure of UniProt P42575
- Elsewhere: RCSB PDB 6SAD · PDBe 6SAD · UniProt P61981 · UniProt P42575
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.