Research workbench
Crystal structure of the N-terminal domain of the wild type parasitic PEX14
Analyse Crystal structure of the N-terminal domain of the wild type parasitic PEX14 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6S9Y
- Type
- protein
- Length
- 250 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxin 14
- UniProt
- Q8IEW2
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Peroxin 14 | protein | 62 | 73% helix, 0% strand | Q8IEW2 |
| B, D | Peroxin 14 | protein | 63 | 71% helix, 0% strand | Q8IEW2 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains B, C, A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.59 | 0.76 | 32 | empty |
Interfaces
4 interfaces between chains.
- A–D · 491 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 481 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 253 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 251 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6S9Y · Crystal structure of the N-terminal domain of the wild type parasitic PEX14 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IEW2
- Elsewhere: RCSB PDB 6S9Y · PDBe 6S9Y · UniProt Q8IEW2
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