UniProt Q8IEW2
Peroxin 14 (Q8IEW2)
Peroxin 14 (UniProt Q8IEW2): 21 experimental structures on GenesisL1, 11 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8IEW2
- Protein
- Peroxin 14
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 9 · 3 records with a druggable one
Structures
21 records of Q8IEW2 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5AON | Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei | x-ray diffraction | A, B, C, D, E | — | — |
| 5AON | Crystal structure of the conserved N-terminal domain of PEX14 from trypanosoma brucei | x-ray diffraction | A, B, C, D, E | — | — |
| 5L87 | Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat… | x-ray diffraction | A | 6RD | — |
| 5L87 | Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat… | x-ray diffraction | A | 6RD | — |
| 5L8A | Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat… | x-ray diffraction | A, B, C, D | 6RB, NA | — |
| 5L8A | Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat… | x-ray diffraction | A, B, C, D | 6RB, NA | — |
| 5MMC | Trypanosoma brucei Pex14 N-terminal domain | solution nmr | A | — | — |
| 5MMC | Trypanosoma brucei PEX14 N-terminal domain | solution nmr | A | — | — |
| 5N8V | Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat… | x-ray diffraction | A, B, D, F | KZZ, SO4, CL | 3 (best 0.38) |
| 5N8V | Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat… | x-ray diffraction | A, B, D, F | KZZ, SO4, CL | — |
| 5OML | Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules to… | x-ray diffraction | A, B, C, D | 9YB, SO4 | — |
| 5OML | Crystal structure of trypanosoma brucei PEX14 N-terminal domain in complex with small molecules to… | x-ray diffraction | A, B, C, D | 9YB, SO4 | — |
| 6RT2 | Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules… | x-ray diffraction | A, B, C, D | CV5, SO4 | 3 (best 0.62) |
| 6RT2 | Crystal structure of trypanosoma brucei PEX14 N-terminal domain in complex with small molecules… | x-ray diffraction | A, B, C, D | CV5, SO4 | — |
| 6S6R | First crystal structure of parasitic PEX14 in complex with a fragment molecule… | x-ray diffraction | A | SO4, KXQ | — |
| 6S7M | Structure of parasitic PEX14 in complex with a benzo[b]thiophene-7-carboxylic acid. | x-ray diffraction | A, B, C, D, E, F, G, H | KZ2 | 2 (best 0.73) |
| 6S7M | Structure of parasitic PEX14 in complex with a BENZO[B]THIOPHENE-7- carboxylic acid. | x-ray diffraction | A, B, C, D, E, F, G, H | KZ2 | — |
| 6S9Y | Crystal structure of the N-terminal domain of the wild type parasitic PEX14 | x-ray diffraction | A, B, C, D | — | 1 (best 0.59) |
| 6S9Y | Crystal structure of the N-terminal domain of the wild type parasitic PEX14 | x-ray diffraction | A, B, C, D | — | — |
| 6SPT | High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex… | x-ray diffraction | A | FTW, CL | — |
| 6SPT | High resolution crystal structure of N-terminal domain of PEX14 from trypanosoma brucei in complex… | x-ray diffraction | A | FTW, CL | — |
Ligands
- SO4 · Sulfate ion · in 7 records
- CL · Chloride ion · in 4 records
- 6RB · 1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl) methyl]-~{N}-(phenylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide · in 2 records
- 6RD · 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide · in 2 records
- 9YB · (3~{R})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid · in 2 records
- CV5 · (3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid · in 2 records
- FTW · 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide · in 2 records
- KZ2 · 1-benzothiophene-7-carboxylic acid · in 2 records
- KZZ · 1-(2-azanylethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide · in 2 records
- NA · Sodium ion · in 2 records
- KXQ · 1~{H}-indole-7-carboxylic acid · in 1 record
Elsewhere
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