Research workbench
Human BRR2 helicase region M641C/A1582C
Analyse Human BRR2 helicase region M641C/A1582C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6S8O
- Type
- protein
- Length
- 1,724 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U5 small nuclear ribonucleoprotein 200 kda helicase
- EC
- 3.6.4.13
- UniProt
- O75643
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | U5 small nuclear ribonucleoprotein 200 kda helicase (EC 3.6.4.13) | protein | 1724 | 38% helix, 15% strand | O75643 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 800 | 0.86 | 0.88 | 94 | empty |
| 2 | 1099 | 0.81 | 0.82 | 97 | empty |
| 3 | 569 | 0.79 | 0.85 | 54 | empty |
| 4 | 645 | 0.71 | 0.79 | 50 | empty |
| 5 | 286 | 0.71 | 0.85 | 44 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6S8O · Human Brr2 Helicase Region M641C/A1582C · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75643
- Elsewhere: RCSB PDB 6S8O · PDBe 6S8O · UniProt O75643
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