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Crystal structure of zinc free A14E, B25H, B29K(N(EPS)-[2-(2-[2-(2-[2- (octadecandioyl-gamma-GLU)AMINO]ETHOXY)ETHOXY]ACETYLAMINO) ETHOXY]ETHOXY)ACETYL]), DESB27, DESB30 human insulin

Analyse Crystal structure of zinc free A14E, B25H, B29K(N(EPS)-[2-(2-[2-(2-[2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6S4J
Type: protein
Length: 49 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin
UniProt: P01308
Ligands: KUT

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin	protein	21	57% helix, 5% strand	P01308
B	Insulin	protein	28	50% helix, 4% strand	P01308

Ligands and binding sites

KUT · Kut [2-(2-[2-(2-[2-(octadecandioyl-gamma-glu) amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] · ligand · chains A, B
IMD · Imidazole · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 775 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide, 1 covalent (disulfide, covalent ligand).

Compared structures

6S4J · Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamm… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 6S4J · PDBe 6S4J · UniProt P01308

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