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Structure of the ternary complex of the impdh enzyme from ashbya gossypii bound to the dinucleoside polyphosphate AP5G and GDP
Analyse Structure of the ternary complex of the impdh enzyme from ashbya gossypii bound… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RPU
- Type
- protein
- Length
- 432 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- UniProt
- Q756Z6
- Ligands
- G5P, GDP
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 432 | 38% helix, 18% strand | Q756Z6 |
Ligands and binding sites
- G5P · P1-(5'-adenosyl)-P5-(5'-guanosyl) pentaphosphate · ligand · chains A
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- ACT · Acetate ion · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.52 | 0.79 | 24 | G5P |
| 2 | 87 | 0.43 | 0.80 | 14 | empty |
| 3 | 83 | 0.37 | 0.76 | 14 | G5P |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 6RPU · Structure of the ternary complex of the IMPDH enzyme from Ashbya gossypii bound to the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q756Z6
- Elsewhere: RCSB PDB 6RPU · PDBe 6RPU · UniProt Q756Z6
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