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Crystal structure of the ligand-binding domain of the EPHB2 receptor tyrosine kinase

Analyse Crystal structure of the ligand-binding domain of the EPHB2 receptor tyrosine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NUK
Type: protein
Length: 169 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (tyrosine-protein kinase receptor eph)
EC: 2.7.1.112
UniProt: P54763
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (tyrosine-protein kinase receptor eph) (EC 2.7.1.112)	protein	169	2% helix, 40% strand	P54763

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.31	0.76	14	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1NUK · Crystal structure of the ligand-binding domain of the EPHB2 receptor tyrosine kinase · the same entry in another collection · chain A against A, TM-score 1.00
P54763 · AlphaFold monomer V2.0 prediction for ephrin type-B receptor 2 (P54763) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54763
Elsewhere: RCSB PDB 1NUK · PDBe 1NUK · UniProt P54763

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