UniProt P54763
Ephrin type-B receptor 2 (P54763)
Ephrin type-B receptor 2 (UniProt P54763), EC 2.7.1.112, 2.7.10.1: 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P54763
- Protein
- Ephrin type-B receptor 2
- EC
- 2.7.1.112, 2.7.10.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 38 · 4 records with a druggable one
Structures
15 records of P54763 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JPA | Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region | x-ray diffraction | A, B | ANP | 3 (best 0.75) |
| 1JPA | Crystal structure of unphosphorylated EPHB2 receptor tyrosine kinase and juxtamembrane region | x-ray diffraction | A, B | — | — |
| 1KGY | Crystal Structure of the EphB2-ephrinB2 complex | x-ray diffraction | A, B, C, D | — | 19 (best 0.69) |
| 1KGY | Crystal structure of the EPHB2-EPHRINB2 complex | x-ray diffraction | A, B, C, D | — | — |
| 1NUK | Crystal structure of the ligand-binding domain of the EPHB2 receptor tyrosine kinase | x-ray diffraction | A | — | 1 (best 0.31) |
| 1NUK | Crystal structure of the ligand-binding domain of the EPHB2 receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 1SHW | EphB2 / EphrinA5 Complex Structure | x-ray diffraction | B | — | 4 (best 0.70) |
| 1SHW | EPHB2 / EPHRINA5 complex structure | x-ray diffraction | B | — | — |
| 2HEN | Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP | x-ray diffraction | A, B, C, D | MG, ADP | 9 (best 0.65) |
| 2HEN | Crystal structure of the EPHB2 receptor kinase domain in complex with ADP | x-ray diffraction | A, B, C, D | — | — |
| 3ETP | The crystal structure of the ligand-binding domain of the EphB2 receptor at 2.0 A resolution | x-ray diffraction | A | — | 1 (best 0.28) |
| 3ETP | The crystal structure of the ligand-binding domain of the EPHB2 receptor at 2.0 a resolution | x-ray diffraction | A | — | — |
| 7S7K | Crystal structure of the EphB2 extracellular domain | x-ray diffraction | A | NAG | 1 (best 0.40) |
| 7S7K | Crystal structure of the EPHB2 extracellular domain | x-ray diffraction | A | NAG | — |
| P54763 | AlphaFold monomer V2.0 prediction for ephrin type-B receptor 2 (P54763) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1JPA chain B against the predicted model P54763: TM-score 0.99, RMSD 0.65 Å
- 1JPA chain B against the predicted model P54763: TM-score 0.99, RMSD 0.65 Å
- 1JPA chain A against the predicted model P54763: TM-score 0.99, RMSD 0.66 Å
- 1JPA chain A against the predicted model P54763: TM-score 0.99, RMSD 0.66 Å
- 2HEN chain B against the predicted model P54763: TM-score 0.99, RMSD 0.74 Å
- 2HEN chain B against the predicted model P54763: TM-score 0.99, RMSD 0.74 Å
- 2HEN chain D against the predicted model P54763: TM-score 0.99, RMSD 0.74 Å
- 2HEN chain D against the predicted model P54763: TM-score 0.99, RMSD 0.74 Å
- 2HEN chain A against the predicted model P54763: TM-score 0.99, RMSD 0.76 Å
- 2HEN chain A against the predicted model P54763: TM-score 0.99, RMSD 0.76 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.