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Cryoem structure of calcium-free human TMEM16K / anoctamin 10 in detergent (closed form)

Analyse Cryoem structure of calcium-free human TMEM16K / anoctamin 10 in detergent… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6R7Z
Type: protein
Length: 1,228 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anoctamin-10
UniProt: Q9NW15
Pockets: 16 · best druggability 0.78

Structure

electron microscopy · 1 distinct chain · 61% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Anoctamin-10	protein	614	61% helix, 7% strand	Q9NW15

Pockets

16 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	537	0.78	0.85	72	empty
2	410	0.77	0.86	69	empty
3	660	0.77	0.82	73	empty
4	617	0.76	0.82	65	empty
5	475	0.75	0.84	74	empty

Interfaces

1 interface between chains.

A–B · 367 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6R7Z · CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form) · the same entry in another collection · chain A against A, TM-score 1.00
Q9NW15 · AlphaFold monomer V2.0 prediction for anoctamin-10 (Q9NW15) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NW15
Elsewhere: RCSB PDB 6R7Z · PDBe 6R7Z · UniProt Q9NW15

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