Major aspartyl peptidase 1 from C. neoformans

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 44% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• NA · Sodium ion · metal · 2 copies · chains A
• SO4 · Sulfate ion · ion · 4 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 7 copies · chains A
• PGE · Triethylene glycol · additive · chains A
• EDO · 1,2-ethanediol · additive · chains A
• ACY · Acetic acid · additive · chains A
• PG4 · Tetraethylene glycol · additive · chains A
• 1PE · Pentaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 6R5H · Major aspartyl peptidase 1 from C. neoformans · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt J9VS02
• Elsewhere: RCSB PDB 6R5H · PDBe 6R5H · UniProt J9VS02