Research workbench
C-SH2 domain of shp-2 in complex with phospho-itsm of pd-1
Analyse C-SH2 domain of shp-2 in complex with phospho-itsm of pd-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6R5G
- Type
- protein
- Length
- 130 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 11; Itsm
- EC
- 3.1.3.48
- UniProt
- Q06124
Structure
solution nmr · 2 distinct chains · 16% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) | protein | 119 | 18% helix, 29% strand | Q06124 |
| B | Itsm | protein | 11 | 0% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 739 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6R5G · C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 6R5G · PDBe 6R5G · UniProt Q06124
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