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The crystal structure of antibody N10-staphylococcal nuclease complex at 2.9 ångströms resolution
Analyse The crystal structure of antibody N10-staphylococcal nuclease complex at 2.9… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NSN
- Type
- protein
- Length
- 565 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IgG Fab (IGG1, kappa); Staphylococcal nuclease
- EC
- 3.1.31.1
- UniProt
- P00644
- Pockets
- 7 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IgG Fab (IGG1, kappa) | protein | 217 | 6% helix, 47% strand | — |
| H | IgG Fab (IGG1, kappa) | protein | 210 | 4% helix, 48% strand | — |
| S | Staphylococcal nuclease (EC 3.1.31.1) | protein | 138 | 25% helix, 28% strand | P00644 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 660 | 0.84 | 0.88 | 68 | empty |
| 2 | 404 | 0.56 | 0.74 | 48 | empty |
| 3 | 123 | 0.41 | 0.76 | 25 | empty |
| 4 | 70 | 0.39 | 0.78 | 17 | empty |
| 5 | 108 | 0.36 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1568 Ų buried · 15 hydrogen bonds · protein-protein
- L–S · 524 Ų buried · 5 hydrogen bonds · protein-protein
- H–S · 488 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1NSN · The crystal structure of antibody N10-staphylococcal nuclease complex at 2.9 ångströms… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00644
- Elsewhere: RCSB PDB 1NSN · PDBe 1NSN · UniProt P00644
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