UniProt P00644
Thermonuclease (P00644)
Thermonuclease (UniProt P00644), EC 3.1.31.1: 564 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00644
- Protein
- Thermonuclease
- EC
- 3.1.31.1
- Experimental structures
- 564
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 21 · 4 records with a druggable one
Structures
565 records of P00644 in the MolNFT archive: 564 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A2T | Staphylococcal nuclease, B-mercaptoethanol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1A2T | Staphylococcal nuclease, B-mercaptoethanol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1A2U | Staphylococcal nuclease, V23C variant, complex with 1-N-butane thiol and 3',5'-thymidine diphosphate | x-ray diffraction | A | — | — |
| 1A2U | Staphylococcal nuclease, V23C variant, complex with 1-N-butane thiol and 3',5'-thymidine diphosphate | x-ray diffraction | A | — | — |
| 1A3T | Staphylococcal nuclease, V23C variant, complex with 2-fluoroethane thiol and 3',5'-thymidine… | x-ray diffraction | A | — | — |
| 1A3T | Staphylococcal nuclease, V23C variant, complex with 2-fluoroethane thiol and 3',5'-thymidine… | x-ray diffraction | A | — | — |
| 1A3U | Staphylococcal nuclease, cyclohexane thiol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1A3U | Staphylococcal nuclease, cyclohexane thiol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1A3V | Staphylococcal nuclease, cyclopentane thiol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1A3V | Staphylococcal nuclease, cyclopentane thiol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1AEX | Staphylococcal nuclease, methane thiol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1AEX | Staphylococcal nuclease, methane thiol disulfide to V23C variant | x-ray diffraction | A | — | — |
| 1ENA | Crystal structures of the binary CA2+ and pdtp complexes and the ternary complex of the asp 21->glu… | x-ray diffraction | A | — | — |
| 1ENA | Crystal structures of the binary CA2+ and pdtp complexes and the ternary complex of the asp 21->glu… | x-ray diffraction | A | — | — |
| 1ENC | Crystal structures of the binary CA2+ and pdtp complexes and the ternary complex of the asp 21->glu… | x-ray diffraction | A | — | — |
| 1ENC | Crystal structures of the binary CA2+ and pdtp complexes and the ternary complex of the asp 21->glu… | x-ray diffraction | A | — | — |
| 1EQV | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1EQV | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1EY0 | Structure of wild-type S. nuclease at 1.6 a resolution | x-ray diffraction | A | — | — |
| 1EY0 | Structure of wild-type S. nuclease at 1.6 a resolution | x-ray diffraction | A | — | — |
| 1EY4 | Structure of S. nuclease stabilizing mutant S59A | x-ray diffraction | A | — | — |
| 1EY4 | Structure of S. nuclease stabilizing mutant S59A | x-ray diffraction | A | — | — |
| 1EY5 | Structure of S. nuclease stabilizing mutant T33V | x-ray diffraction | A | — | — |
| 1EY5 | Structure of S. nuclease stabilizing mutant T33V | x-ray diffraction | A | — | — |
| 1EY6 | Structure of S. nuclease stabilizing mutant T41I | x-ray diffraction | A | — | — |
| 1EY6 | Structure of S. nuclease stabilizing mutant T41I | x-ray diffraction | A | — | — |
| 1EY7 | Structure of S. nuclease stabilizing mutant S128A | x-ray diffraction | A | — | — |
| 1EY7 | Structure of S. nuclease stabilizing mutant S128A | x-ray diffraction | A | — | — |
| 1EY8 | Structure of S. nuclease stabilizing triple mutant P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EY8 | Structure of S. nuclease stabilizing triple mutant P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EY9 | Structure of S. nuclease stabilizing quadruple mutant T41I/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EY9 | Structure of S. nuclease stabilizing quadruple mutant T41I/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EYA | Structure of S. nuclease stabilizing quintuple mutant T33V/T41I/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EYA | Structure of S. nuclease stabilizing quintuple mutant T33V/T41I/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EYC | Structure of S. nuclease stabilizing quintuple mutant T41I/S59A/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EYC | Structure of S. nuclease stabilizing quintuple mutant T41I/S59A/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EYD | Structure of wild-type S. nuclease at 1.7 a resolution | x-ray diffraction | A | — | — |
| 1EYD | Structure of wild-type S. nuclease at 1.7 a resolution | x-ray diffraction | A | — | — |
| 1EZ6 | Structure of S. nuclease stabilizing sextuple mutant T33V/T41I/S59A/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EZ6 | Structure of S. nuclease stabilizing sextuple mutant T33V/T41I/S59A/P117G/H124L/S128A | x-ray diffraction | A | — | — |
| 1EZ8 | Structure of S. nuclease stabilizing mutant T33V | x-ray diffraction | A | — | — |
| 1EZ8 | Structure of S. nuclease stabilizing mutant T33V | x-ray diffraction | A | — | — |
| 1F2M | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1F2M | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1F2Y | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1F2Y | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1F2Z | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1F2Z | Simplification of a protein loop in staphylococcal nuclease | x-ray diffraction | A | — | — |
| 1IHZ | Structure of S. nuclease mutant quintuple mutant V23L/V66L/I72L/I92L/V99L | x-ray diffraction | A | — | — |
| 1IHZ | Structure of S. nuclease mutant quintuple mutant V23L/V66L/I72L/I92L/V99L | x-ray diffraction | A | — | — |
| 1II3 | Structure of S. nuclease quintuple mutant V23I/V66L/I72L/I92L/V99L | x-ray diffraction | A | — | — |
| 1II3 | Structure of S. nuclease quintuple mutant V23I/V66L/I72L/I92L/V99L | x-ray diffraction | A | — | — |
| 1JOK | Averaged structure for Staphylococcal nuclease-H124L in ternary complex with Ca2+ and… | solution nmr | A | — | — |
| 1JOK | Averaged structure for staphylococcal nuclease-H124L in ternary complex with CA2+ and… | solution nmr | A | — | — |
| 1JOO | Averaged structure for unligated Staphylococcal nuclease-H124L | solution nmr | A | — | — |
| 1JOO | Averaged structure for unligated staphylococcal nuclease-H124L | solution nmr | A | — | — |
| 1JOQ | Ensemble structures for Staphylococcal nuclease-H124L in ternary complex with Ca2+ and… | solution nmr | A | — | — |
| 1JOQ | Ensemble structures for staphylococcal nuclease-H124L in ternary complex with CA2+ and… | solution nmr | A | — | — |
| 1JOR | Ensemble structures for unligated Staphylococcal nuclease-H124L | solution nmr | A | — | — |
| 1JOR | Ensemble structures for unligated staphylococcal nuclease-H124L | solution nmr | A | — | — |
505 records more on the page itself.
Ligands
Experiment against prediction
- 5CV9 chain A against the predicted model P00644: TM-score 0.99, RMSD 0.36 Å
- 5CC4 chain A against the predicted model P00644: TM-score 0.99, RMSD 0.37 Å
- 5CV4 chain A against the predicted model P00644: TM-score 0.99, RMSD 0.37 Å
- 5IGB chain A against the predicted model P00644: TM-score 0.99, RMSD 0.38 Å
- 1TR5 chain A against the predicted model P00644: TM-score 0.99, RMSD 0.39 Å
- 5IGF chain A against the predicted model P00644: TM-score 0.99, RMSD 0.39 Å
- 5CV6 chain A against the predicted model P00644: TM-score 0.99, RMSD 0.40 Å
- 1TT2 chain A against the predicted model P00644: TM-score 0.99, RMSD 0.41 Å
- 1ENA chain A against the predicted model P00644: TM-score 0.99, RMSD 0.44 Å
- 2OEO chain A against the predicted model P00644: TM-score 0.99, RMSD 0.47 Å
Elsewhere
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