Research workbench
Signal recognition particle receptor beta-subunit in complex with the srx domain from the alpha-subunit
Analyse Signal recognition particle receptor beta-subunit in complex with the srx… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NRJ
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Signal recognition particle receptor alpha subunit homolog; Signal recognition particle…
- UniProt
- P32916, P36057
- Ligands
- GTP, MG
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Signal recognition particle receptor alpha subunit homolog | protein | 147 | 37% helix, 24% strand | P32916 |
| B | Signal recognition particle receptor beta subunit | protein | 191 | 43% helix, 18% strand | P36057 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.57 | 0.80 | 33 | MG, GTP |
| 2 | 161 | 0.45 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1082 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1NRJ · Signal Recognition Particle Receptor Beta-Subunit in Complex with the SRX Domain from the… · the same entry in another collection · chain A against A, TM-score 1.00
- P36057 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor subunit beta… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P32916 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor subunit alpha… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32916
- Every structure of UniProt P36057
- Elsewhere: RCSB PDB 1NRJ · PDBe 1NRJ · UniProt P32916 · UniProt P36057
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