Research workbench
Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif
Analyse Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QNN
- Type
- protein
- Length
- 373 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Clathrin heavy chain 1; G2 and S phase-expressed protein 1
- UniProt
- Q00610, Q9NYZ3
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Clathrin heavy chain 1 | protein | 354 | 6% helix, 53% strand | Q00610 |
| B | G2 and S phase-expressed protein 1 | protein | 19 | 0% helix, 5% strand | Q9NYZ3 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 545 | 0.71 | 0.80 | 65 | empty |
| 2 | 107 | 0.39 | 0.75 | 19 | empty |
| 3 | 57 | 0.30 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 663 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6QNN · Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif · the same entry in another collection · chain A against A, TM-score 1.00
- Q00610 · AlphaFold monomer V2.0 prediction for clathrin heavy chain 1 (Q00610) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9NYZ3 · AlphaFold monomer V2.0 prediction for G2 and S phase-expressed protein 1 (Q9NYZ3) · a predicted model of the same protein · chain B against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00610
- Every structure of UniProt Q9NYZ3
- Elsewhere: RCSB PDB 6QNN · PDBe 6QNN · UniProt Q00610 · UniProt Q9NYZ3
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