Research workbench
Cryo-EM structure of calcium-free NHTMEM16 lipid scramblase in ddm
Analyse Cryo-EM structure of calcium-free NHTMEM16 lipid scramblase in ddm in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QM6
- Type
- protein
- Length
- 1,344 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Predicted protein
- UniProt
- C7Z7K1
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Predicted protein | protein | 672 | 64% helix, 5% strand | C7Z7K1 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.76 | 0.79 | 111 | empty |
| 2 | 515 | 0.72 | 0.81 | 59 | empty |
| 3 | 677 | 0.66 | 0.75 | 59 | empty |
| 4 | 623 | 0.65 | 0.75 | 52 | empty |
| 5 | 171 | 0.61 | 0.84 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 4932 Ų buried · 49 hydrogen bonds · protein-protein
Compared structures
- 6QM6 · Cryo-EM structure of calcium-free nhTMEM16 lipid scramblase in DDM · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7Z7K1
- Elsewhere: RCSB PDB 6QM6 · PDBe 6QM6 · UniProt C7Z7K1
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