Research workbench
Cryo-EM structure of calcium-free NHTMEM16 lipid scramblase in nanodisc
Analyse Cryo-EM structure of calcium-free NHTMEM16 lipid scramblase in nanodisc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QM4
- Type
- protein
- Length
- 1,308 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Predicted protein
- UniProt
- C7Z7K1
- Pockets
- 18 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Predicted protein | protein | 654 | 65% helix, 4% strand | C7Z7K1 |
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 839 | 0.80 | 0.82 | 76 | empty |
| 2 | 771 | 0.78 | 0.82 | 75 | empty |
| 3 | 602 | 0.74 | 0.81 | 71 | empty |
| 4 | 472 | 0.73 | 0.82 | 63 | empty |
| 5 | 461 | 0.72 | 0.82 | 60 | empty |
Interfaces
1 interface between chains.
- A–B · 4284 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- 6QM4 · Cryo-EM structure of calcium-free nhTMEM16 lipid scramblase in nanodisc · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7Z7K1
- Elsewhere: RCSB PDB 6QM4 · PDBe 6QM4 · UniProt C7Z7K1
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