Research workbench
Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA
Analyse Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QHD
- Type
- protein + DNA
- Length
- 1,098 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Signal transducer and activator of transcription 3; DNA (5'…
- UniProt
- P40763
- Pockets
- 17 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 48% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Signal transducer and activator of transcription 3 | protein | 530 | 47% helix, 16% strand | P40763 |
| B | Signal transducer and activator of transcription 3 | protein | 532 | 48% helix, 17% strand | P40763 |
| C | DNA (5'- D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3') | dna | 18 | — | — |
| D | DNA (5'- D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3') | dna | 18 | — | — |
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 646 | 0.69 | 0.78 | 44 | empty |
| 2 | 462 | 0.67 | 0.79 | 41 | empty |
| 3 | 497 | 0.67 | 0.78 | 52 | empty |
| 4 | 503 | 0.67 | 0.79 | 56 | empty |
| 5 | 170 | 0.58 | 0.82 | 26 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1382 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 775 Ų buried · 72 hydrogen bonds · nucleic-nucleic
- B–D · 409 Ų buried · 7 hydrogen bonds · protein-nucleic
- A–C · 385 Ų buried · 6 hydrogen bonds · protein-nucleic
- A–D · 314 Ų buried · 6 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified (acetylation, phosphorylation).
Compared structures
- 6QHD · Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA · the same entry in another collection · chain A against A, TM-score 1.00
- P40763 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 3… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40763
- Elsewhere: RCSB PDB 6QHD · PDBe 6QHD · UniProt P40763
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