UniProt P40763
Signal transducer and activator of transcription 3 (P40763)
Signal transducer and activator of transcription 3 (UniProt P40763): 7 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 40 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P40763
- Protein
- Signal transducer and activator of transcription 3
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 40 · 3 records with a druggable one
Structures
8 records of P40763 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NJS | STAT3 core in complex with compound SD36 | x-ray diffraction | A | KQV | — |
| 6NUQ | Stat3 Core in complex with compound SI109 | x-ray diffraction | A | KQV | — |
| 6NUQ | STAT3 core in complex with compound SI109 | x-ray diffraction | A | KQV | — |
| 6QHD | Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA | x-ray diffraction | A, B | — | 17 (best 0.69) |
| 6QHD | Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA | x-ray diffraction | A, B | — | — |
| 6TLC | Unphosphorylated human STAT3 in complex with MS3-6 monobody | x-ray diffraction | B, A | — | 16 (best 0.53) |
| 6TLC | Unphosphorylated human STAT3 in complex with MS3-6 monobody | x-ray diffraction | B, A | — | — |
| P40763 | AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 3 (P40763) | predicted | A | — | 7 (best 0.69) |
Ligands
- KQV · [(2-{[(5s,8s,10ar)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-A][1, 5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro) methyl]phosphonic acid (non-preferred name) · in 3 records
Experiment against prediction
- 6QHD chain A against the predicted model P40763: TM-score 0.99, RMSD 0.90 Å
- 6QHD chain A against the predicted model P40763: TM-score 0.99, RMSD 0.90 Å
- 6QHD chain B against the predicted model P40763: TM-score 0.99, RMSD 0.94 Å
- 6QHD chain B against the predicted model P40763: TM-score 0.99, RMSD 0.94 Å
- 6NJS chain A against the predicted model P40763: TM-score 0.99, RMSD 0.99 Å
- 6NUQ chain A against the predicted model P40763: TM-score 0.99, RMSD 1.00 Å
- 6NUQ chain A against the predicted model P40763: TM-score 0.99, RMSD 1.00 Å
- 6TLC chain B against the predicted model P40763: TM-score 0.95, RMSD 2.04 Å
- 6TLC chain B against the predicted model P40763: TM-score 0.95, RMSD 2.04 Å
- 6TLC chain A against the predicted model P40763: TM-score 0.95, RMSD 2.09 Å
Elsewhere
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