Research workbench
Structure of human BCL-2 in complex with puma BH3 peptide
Analyse Structure of human BCL-2 in complex with puma BH3 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QG8
- Type
- protein
- Length
- 156 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator BCL-2,BCL-2-like protein 1,APOPTOSIS regulator BCL-2,BCL-2-like…
- UniProt
- P10415, Q07817, Q9BXH1
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator BCL-2,BCL-2-like protein 1,APOPTOSIS regulator BCL-2,BCL-2-like protein 1 | protein | 137 | 77% helix, 0% strand | P10415, Q07817 |
| B | BCL-2-binding component 3 | protein | 19 | 89% helix, 0% strand | Q9BXH1 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.47 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 832 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6QG8 · Structure of human Bcl-2 in complex with PUMA BH3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P10415 · AlphaFold monomer V2.0 prediction for apoptosis regulator BCL-2 (P10415) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9BXH1 · AlphaFold monomer V2.0 prediction for BCL-2-binding component 3, isoforms 1/2 (Q9BXH1) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10415
- Every structure of UniProt Q07817
- Every structure of UniProt Q9BXH1
- Elsewhere: RCSB PDB 6QG8 · PDBe 6QG8 · UniProt P10415 · UniProt Q07817 · UniProt Q9BXH1
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