Crystal structure of human methionine aminopeptidase-2 in complex with an inhibitor thiophene-2-sulfonic acid (4-fluoro-benzyl)-(4H-[1,2, 4]TRIAZOL-3-ylmethyl)-amide

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 26% strand (DSSP).

Ligands and binding sites

• HZT · ~{N}-[(4-fluorophenyl)methyl]-~{N}-(1~{H}-1,2,4-triazol-5-ylmethyl)thiophene-2-sulfonamide · ligand · chains A
• MN · Manganese (II) ion · metal · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · chains A
• TBU · Tertiary-butyl alcohol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 6QEJ · CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR… · the same entry in another collection · chain A against A, TM-score 1.00
• P50579 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase 2 (P50579) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P50579
• Elsewhere: RCSB PDB 6QEJ · PDBe 6QEJ · UniProt P50579