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Anti-sigma factor domain-containing protein

Analyse Anti-sigma factor domain-containing protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6QE7
Type: protein
Length: 864 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-sigma-I factor RSGI3
UniProt: A3DC75
Ligands: CA
Pockets: 6 · best druggability 0.63

Structure

x-ray diffraction · 3 distinct chains · 2% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anti-sigma-I factor RSGI3	protein	291	2% helix, 53% strand	A3DC75
B	Anti-sigma-I factor RSGI3	protein	287	2% helix, 55% strand	A3DC75
C	Anti-sigma-I factor RSGI3	protein	286	2% helix, 55% strand	A3DC75

Ligands and binding sites

CA · Calcium ion · metal · 6 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	602	0.63	0.75	70	empty
2	483	0.62	0.76	63	empty
3	548	0.62	0.75	59	empty
4	94	0.33	0.73	14	empty
5	80	0.31	0.73	14	empty

Interfaces

3 interfaces between chains.

A–C · 507 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 506 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 488 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6QE7 · anti-sigma factor domain-containing protein · the same entry in another collection · chain A against A, TM-score 1.00
A3DC75 · AlphaFold monomer V2.0 prediction for anti-sigma-I factor RSGI3 (A3DC75) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A3DC75
Elsewhere: RCSB PDB 6QE7 · PDBe 6QE7 · UniProt A3DC75

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