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Structure of an anti-MCL1 scfv

Analyse Structure of an anti-MCL1 scfv in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6QB9
Type: protein
Length: 473 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SCFV55
Pockets: 4 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SCFV55	protein	237	5% helix, 49% strand	—
X	SCFV55	protein	236	5% helix, 50% strand	—

Ligands and binding sites

TLA · L(+)-tartaric acid · additive · 2 copies · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.49	0.80	24	empty
2	146	0.48	0.78	28	empty
3	66	0.36	0.77	13	empty
4	61	0.35	0.77	12	empty

Interfaces

1 interface between chains.

A–X · 50 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6QB9 · Structure of an anti-Mcl1 scFv · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6QB9 · PDBe 6QB9

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