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Nterminal domain of human SMU1 in complex with human redmid

Analyse Nterminal domain of human SMU1 in complex with human redmid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6Q8I
Type: protein
Length: 1,774 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: WD40 repeat-containing protein SMU1; Protein red
UniProt: Q2TAY7, Q13123
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 13 distinct chains · 58% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	WD40 repeat-containing protein SMU1	protein	187	66% helix, 5% strand	Q2TAY7
B	WD40 repeat-containing protein SMU1	protein	182	68% helix, 4% strand	Q2TAY7
C	Protein red	protein	41	22% helix, 12% strand	Q13123
D, P	Protein red	protein	37	24% helix, 19% strand	Q13123
E, I, M	WD40 repeat-containing protein SMU1	protein	186	67% helix, 5% strand	Q2TAY7
F	WD40 repeat-containing protein SMU1	protein	167	67% helix, 4% strand	Q2TAY7
G	Protein red	protein	45	20% helix, 16% strand	Q13123
H	Protein red	protein	36	25% helix, 19% strand	Q13123
J	WD40 repeat-containing protein SMU1	protein	183	68% helix, 4% strand	Q2TAY7
K	Protein red	protein	40	25% helix, 20% strand	Q13123
L	Protein red	protein	37	24% helix, 19% strand	Q13123
N	WD40 repeat-containing protein SMU1	protein	185	67% helix, 4% strand	Q2TAY7
O	Protein red	protein	39	23% helix, 18% strand	Q13123

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	830	0.77	0.80	71	empty
2	606	0.75	0.82	55	empty
3	1030	0.75	0.77	77	empty
4	403	0.67	0.80	34	empty
5	383	0.63	0.78	39	empty

Interfaces

36 interfaces between chains.

A–B · 2236 Å² buried · 13 hydrogen bonds · protein-protein
I–J · 2218 Å² buried · 14 hydrogen bonds · protein-protein
E–F · 2215 Å² buried · 14 hydrogen bonds · protein-protein
M–N · 2103 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 1144 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6Q8I · Nterminal domain of human SMU1 in complex with human REDmid · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2TAY7
Every structure of UniProt Q13123
Elsewhere: RCSB PDB 6Q8I · PDBe 6Q8I · UniProt Q2TAY7 · UniProt Q13123

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