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Cryo-EM structure of the respiratory syncytial virus polymerase (L) protein bound by the tetrameric phosphoprotein (P)
Analyse Cryo-EM structure of the respiratory syncytial virus polymerase (L) protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PZK
- Type
- protein
- Length
- 1,624 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; Phosphoprotein
- EC
- 2.7.7.48, 2.1.1.56, 2.7.7.-, 2.7.7.88
- UniProt
- P28887, P03421
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 5 distinct chains · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 2.1.1.56, 2.7.7.-, 2.7.7.88) | protein | 1361 | 53% helix, 9% strand | P28887 |
| B | Phosphoprotein | protein | 98 | 55% helix, 12% strand | P03421 |
| C | Phosphoprotein | protein | 57 | 77% helix, 0% strand | P03421 |
| D | Phosphoprotein | protein | 55 | 85% helix, 0% strand | P03421 |
| E | Phosphoprotein | protein | 53 | 89% helix, 0% strand | P03421 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1194 | 0.79 | 0.81 | 115 | empty |
| 2 | 1059 | 0.77 | 0.79 | 72 | empty |
| 3 | 664 | 0.69 | 0.77 | 68 | empty |
| 4 | 282 | 0.62 | 0.80 | 45 | empty |
| 5 | 165 | 0.58 | 0.82 | 33 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2170 Ų buried · 43 hydrogen bonds · protein-protein
- A–C · 1758 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 1312 Ų buried · 10 hydrogen bonds · protein-protein
- D–E · 1284 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 805 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6PZK · Cryo-EM Structure of the Respiratory Syncytial Virus Polymerase (L) Protein Bound by the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28887
- Every structure of UniProt P03421
- Elsewhere: RCSB PDB 6PZK · PDBe 6PZK · UniProt P28887 · UniProt P03421
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